Chronic oxidative stress and telomere shortening
نویسندگان
چکیده
منابع مشابه
Telomere shortening and oxidative stress in aged macrophages results in impaired STAT5a phosphorylation.
Macrophages are an essential component of both innate and adaptive immunity, and altered function of these cells with aging may play a key role in immunosenescence. To determine the effect of aging on macrophages, we produced bone marrow-derived macrophages in vitro. In these conditions, we analyzed the effect of aging on macrophages without the influence of other cell types that may be affecte...
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Introduction Irradiation of normal human fibroblasts with X-rays has been reported to cause an intracellular accumulation of reactive oxygen species (ROS) [1]. The enhanced production of ROS is hypothesised to correlate with a continuous damage to cellular molecules, especially the DNA. In this context, the end-protecting structures of the linear human chromosomes are of particular interest, pl...
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Telomerase is a ribonucleoprotein that counteracts telomere shortening and can immortalise human cells. There is also evidence for a telomere-independent survival function of telomerase. However, its mechanism is not understood. We show here that TERT, the catalytic subunit of human telomerase, protects human fibroblasts against oxidative stress. While TERT maintains telomere length under stand...
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The effects of palm gamma-tocotrienol (GGT) on oxidative stress-induced cellular ageing was investigated in normal human skin fibroblast cell lines derived from different age groups; young (21-year-old, YF), middle (40-year-old, MF) and old (68-year-old, OF). Fibroblast cells were treated with gamma-tocotrienol for 24 hours before or after incubation with IC50 dose of H2O2 for 2 hours. Changes ...
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The main mechanism of pathogenesis which causes systemic complications in obstructive sleep apnea (OSA) patients is believed to be intermittent hypoxia-induced intermediary effect and it depends on the burden of oxidative stress during sleep. We aimed to search the predictive markers which reflect the burden of systemic oxidative stress in patients with OSA and whether excessive telomere length...
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ژورنال
عنوان ژورنال: Chemico-Biological Interactions
سال: 2007
ISSN: 0009-2797
DOI: 10.1016/j.cbi.2007.06.013